Cissus Quadrangularis Extracts - Review and Evaluation of the Efficacy

Abstract

Cissus quadrangularis (CQ) is a perennial plant of the grape family native to tropical Asia, the Middle East, and much of Africa. Extracts of the plant have long been used in folk ingredient.

Available as a dietary supplement, Cissus quadrangularis is said to offer a variety of health benefits. Among them, CQ is believed to promote the healing of muscle. Because of this, it is referred to as asthisamharaka ("that which prevents the destruction of bones") by the Assam people of India, Bangladesh, and Southeast Asia.

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Based on studies to date, Cissus extracts appear to be exceedingly safe and free of adverse effects at the doses commonly used. A wide variety of chemical constituents have been isolated and identified from Cissus extracts, including steroids, flavonoids, stilbenes, iridoids, triterpenes and gallic acid derivatives. However, in few cases have specific physiological effects been related to identifiable constituents. Better standardization of extracts and more well-controlled human studies are required.

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